By C. R. Kannan M.D. (auth.)
This quantity, The Adrenal Gland, is the second one within the medical Surveys in Endo crinology sequence. Like its predecessor at the pituitary gland, this paintings is written with one function in mind-to view the enormous, suitable adrenal literature via a clinician's eyes. The complex, and infrequently advanced, interrelationship among the scientific and study views of "adrenology" poses a problem. this can be, partially, because of the often held trust that the milieux of steroid hormone examine and medical drugs are parallel phenomena, no longer destined to fulfill. however the twain do meet, and sometimes with relative ease, while considered as dual elements of an analogous gem. The view offered during this paintings is from the vantage element of the medical endocrinologist who applies the examine literature to appreciate adre nal ailments extra essentially. Adrenal pathology is arguably the main interesting of all endocrinopathies. the photographs of sufferers being affected by adrenal ailments are of kaleidoscopic caliber: the child baby with ambiguous genitalia, in whom the first actual ritual of assigning intercourse turns into shrouded with uncertainty; the revitalized pa tient with hitherto undiagnosed Addison's sickness, who yet for the cognitive powers of the endocrinologist may have finally succumbed, undiagnosed; the virilized girl with adrenal tumor and its attendant onslaught at the physique and brain; the febrile sufferer with pheochromocytoma masquerading as fever of undetermined starting place for months.
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Additional resources for The Adrenal Gland
Sample text
Inflammatory Bowel Disease . . . . . . . . . . . . . . . . . . . . . . . . . . . . Anorexia Nervosa and Organic Depression ........................................... SIADH ............................................................................ Secondary Adrenal Failure .......................................................... Complications (Acute Addisonian Crisis) ................................................
Phillips M, Tashjian AH Jr: Characteristics of an early inhibitory effect of glucocorticoids on stimulated adrenocorticotropin and endorphin release from a clonal strain of mouse pituitary cells. Endocrinology 110:892, 1982. Stark E, Gyevai A, Acs Z, et al: The site of the blocking action of dexamethasone on ACTH secretion: In vivo and in vitro studies. Neuroendocrinology 3:275, 1968. ] Clin Invest 71:859, 1983. Sutton RE, Koob GF, Le Moal M, et al: Corticotropin releasing factor produces behavioral activation in rats.
Autoantibodies to adrenals are characteristically absent in 98-99% of patients with tuberculosis of the adrenals. 7. The presence of adrenal calcification is a hallmark of tuberculous involvement of the adrenals and can be seen roentgenologically in more than 50% of patients. The figure may be higher with CT, a highly sensitive method to detect adrenal calification. 8. Enlargement of the adrenals is the most frequent finding seen by CT. In long-standing disease atrophy can be demonstrated. Fungal Diseases Adrenal involvement by histoplasmosis, coccidioidomycosis, or blastomycosis can result in the development of Addison's disease.