By Walter Lovenberg and Yukio Yamori (Eds.)
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Extra info for Nutritional Prevention of Cardiovascular Disease
Massive cerebral hemorrhage with ruptured arterionecrosis was occasionally seen in these hypertensive rats ( 7 ) . Electron microscopy of the cerebral arteries in these hypertensive rats revealed intimal fibrin deposits and the fragmented and dissolved internal elastic lamina, both of them were preceded by MMCN and loss. Granular cell debris were seen in the thin tunica media instead of muscle cells (5, 8 ) . IV. HEALING OF MMCN Healing of hypertensive MMCN was studied in male Wistar rats (60-80 g m ) .
The clamp-removal was carried out 4 or 6 weeks 0 4 8 ' • Constriction CI. -Removal Exp. 1 ? Week • Sacrifice O Cont. 1 . Exp. A Cnnt P T t X • Cont. 3 ? 0 Exp. B 4 ? 6 O 10 Week t . Cont. 5 T Cont. 6 t FIGURE 2 . Experimental method of clamp-removal tensive rats for healing of MMCN. : Clamp. in hyper- GENJU OONEDA A N D TOSHINOBU NISHIMURA 30 after the constriction, and after that the rats were allowed to survive for 4 weeks (Exps. 1 and 2 ) . Normal control rats without constriction (Conts. 1 and 4) and hypertensive control rats without clamp-removal (Conts.
42. 51 p. 281. Schattauer Verlag, Stuttgart/New York, 1982. , Circulation 68 (suppl. Ill):384 (1983). , in "Hypertension" (J. Genest, 0. Kuchel, P. Hamet, and M. Cantin, e d s . ) , p . 556. McGraw-Hill, Montreal, 1983. , Life Sci. 19:935 (1976). , Am. J. Physiol. C232:165 (1977). , Horie, R . , Clin. Exp. Pharmacol. Physiol. ): 199 (1976). , Acta. Pathol. Jpn. 32 (suppl. 2):359 (1982). , Horie, R . , in "Prophylactic Approach to Hypertensive Diseases" (Y. Yamori, W. D. Freis, e d s . ) , p. 497.