Life, Death and Nitric Oxide (Rsc Paperbacks) by Anthony R Butler, Rosslyn Nicholson, K B Nolan

By Anthony R Butler, Rosslyn Nicholson, K B Nolan

Specified 'Molecule of the 12 months' in 1992 in reputation of its many organic roles, nitric oxide has vast value on the planet round us and the tale of nitric oxide continues to be unfolding. This small and doubtless blameless molecule has for a few years been recognized to play an important function in either the construction of photochemical smogs and within the nitrogen cycle. It has an engaging chemistry as a steel ligand, and the bonding in the nitric oxide molecule has been largely studied. extra lately, the molecule has been within the highlight for the function it performs in controlling blood circulation, within the immune method and in mind job. existence, dying and Nitric Oxide covers the various subject matters in relation to nitric oxide, from smog and catalytic converters to tumour development, blood stream and Viagra, with the purpose of checking out why this kind of basic molecule can accomplish that a lot.

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Additional info for Life, Death and Nitric Oxide (Rsc Paperbacks)

Sample text

Now that enzyme structures can be obtained with relative ease it is possible that a selective inhibitor can be obtained by design. In spite of an enormous amount of research on NOS (1600 research papers were published on the subject between 1989 and 2000) much remains obscure. NO is one of the smallest molecules to be biologically active and yet its formation needs one of the largest enzymes. Who or whatever is responsible for life on earth (Nature, God or evolution) obviously has a sense of humour.

S. Stamler (eds), Wiley, Chichester, 1996, 71. A. Bellamy in Atti del Convegno in celelbrazione del centenario della morte di Ascanio Sobrero, E. Dagli (ed), Torino, 1989, 15. W. Murrell, Nitro-glycerine as a remedy for angina pectoris. Lancet, 1879, 18 Jan, 80. Q. Chen, J. S. Stamler, Identification of the enzymatic mechanism of nitroglycerine bioactivation. Proc. Natl. Acad. Sci. USA, 2002, 99, 8306. R. Butler and C. Glidewell, Recent chemical studies of sodium nitroprusside relevant to its hypotensive action.

Biol. , 1999, 274, 28983. Chapter 5 Drugs That Release NO Long before NO was known to have a biological role, doctors had been using drugs which, we now know, act by releasing NO. They are effective when the body, for some reason, cannot supply enough NO of its own for dilation of blood vessels on increased demand for blood. One example clarifies the situation. Angina is a distressing medical condition. Its symptoms are a choking or constricting chest pain that occurs behind the breastbone and may radiate to the left arm, to the throat, jaws and teeth, or to the back.

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