By Brand, Eglinton
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The patient was treated with mechanical ventilation and trivalent (A,B,E) equine botulinum antitoxin. Type A toxin was detected in the beans and so was presumably responsible for the symptoms. He made a slow recovery over the next three months. Botulism in the arctic For many years, epidemics of illness have been described in which fish or meat products are responsible. This is relatively common in the Arctic, where over 200 outbreaks have been reported since the early 1900s, with an overall fatality rate of about 20%.
Recently, hepatitis B virus sequences have been found to be integrated into the liver cell genome in some, but not all, patients with chronic hepatitis or primary hepatocellular carcinoma. This evidence has identified hepatitis B virus as a major etiological factor for primary hepatocellular carcinoma in certain populations, particularly in Taiwan and the People’s Republic of China. Some epidemiological studies have suggested that aflatoxin poses no detectable independent carcinogenic risk for man, and that it poses risks only in the presence of other risk factors such as hepatitis B infection.
Carbon monoxide can also be hydrogenated to liquid hydrocarbon fuels and has many applications in bulk chemical manufacture. The toxicity of CO may have been first noted during the 1300s by a Spanish scientist, Arnold of Villanova, who observed that the burning of wood without adequate ventilation gave rise to the production of toxic fumes but it was not until the 1850s that the potential of CO as a toxin was really appreciated when a French physiologist, Claude Bernard, revealed that it combined with the oxygen-carrying protein haemoglobin.